Associate Specialist - Jura Lab

The Jura Lab in the Cardiovascular Research Institute is now recruiting an Associate Specialist. The responsibilities will include design and execution of an independent research project focused on the area of receptor tyrosine kinase signaling, and intra-domain allosteric regulation of receptor tyrosine kinase activity. Various protein expression constructs will be designed and screened for expression and purification from various sources (insect and mammalian cells). Purified protein will be subject to enzymatic analysis in the in vitro kinase assays, and structural analysis by cryo-electron microscopy. In addition, cell-based signaling assays will be conducted to test structural models generated throughout the course of the research project. Other responsibilities will include training and mentoring junior trainees in the lab recruited to work on related projects.

Required Qualifications:

• Specialists appointed at the Associate rank must possess a master's degree (or equivalent degree) or five to ten years of experience in the relevant specialization.
• At least 3 years' experience performing the following experiments: molecular cloning and cDNA mutagenesis; protein expression, purification and biophysical characterization using multi-angle light scattering (MALS) and hydrogen-deuterium mass spectrometry (HDX-MS); structural analysis using X-ray crystallography and cryo-electron microscopy (cryo-EM); and tissue culture, including cell culture maintenance in BSL2 facility, cell transfection using liposome and lentiviral-based methods, Western blot and flow cytometry.

Preferred Qualifications:

• Post-graduate training in field.

Appointees in the Specialist series will be expected to engage in specialized research, professional activities and do not have teaching responsibilities. Specialists are expected to use their professional expertise to make scientific and scholarly contributions, and may participate in University and Public Service. Screening of applicants will begin immediately and will continue as needed throughout the recruitment period. Salary and rank will be commensurate with the applicants experience and training.

See Table 24B for the salary range for this position. A reasonable estimate for this position is $70,500 - $82,100.

Please apply online at https://aprecruit.ucsf.edu/JPF04821.

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.