The Eck lab uses structural, biochemical and biophysical approaches to study protein kinase regulation and other aspects of cellular signal transduction. We use our structural and mechanistic insights to drive development of novel anti-cancer drugs. Systems of current interest in the lab include RAF-family kinases and their control of the RAS/RAF/Map kinase pathway (Park et al., Nature 2019), mutational activation of EGFR in lung cancer (Jia et al., Nature 2016; To et al., Cancer Discov. 2019) and dysregulation of JAK2 in myeloproliferative disorders (McNally et al., ACS Chem Biol. 2019).

Postdoctoral positions are available in the lab (https://ecklab.dana-farber.org/) for curious and mechanistically minded scientists to study these and other areas of interest. The ideal candidate will have a strong background in protein biochemistry with technical expertise in protein expression and purification using mammalian or insect cell systems as well as basic molecular biology techniques. Experience in structural methods (X-ray crystallography, electron microscopy, or NMR), kinase enzymology or assay development/automation is highly desired.

We have state-of-the-art facilities (including for cryo-EM, X-ray crystallography, and mass spectrometry) and a highly collaborative, interdisciplinary environment in Dana-Farber???s Longwood Center. We are part of the Chemical Biology program at the Dana-Farber and the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School.?? We collaborate with disease-focused scientists and medicinal chemists in both industry and academia to pursue new therapeutic approaches inspired and informed by our structural discoveries.

Postdoctoral fellows in the lab bring or learn diverse tools, including:

• Protein expression and purification
• Structure elucidation using Cryo-EM and/or X-ray crystallography
• Enzyme kinetics, binding studies, calorimetry, etc.

A Ph.D. or equivalent doctoral degree in biochemistry or related field

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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