Career Center

The Ziarek lab in the department of Molecular and Cellular Biochemistry at Indiana University invites applications for a Postdoctoral Fellowship. http://www.ziareklab.com/

The long-term vision of our group is to decipher the molecular mechanisms of G protein-coupled receptor (GPCR) allostery for rational drug discovery. There is immense therapeutic potential in the ability to tune receptor signaling using partial agonists, biased agonists or allosteric modulators – and it remains virtually untapped. Our current understanding of biased agonism derives primarily from cell-based functional assays that are easily complicated by receptor expression levels, off-target effects and cell type. Integrating biophysical studies of purified protein with this cellular information will permit a complete molecular understanding. Our work aims to employ a combined biophysical, biochemical, cell-based, and computational approach to characterizing the role of both Monod-Wyman-Changeux (MWC) and dynamically-driven (DD) allosteric mechanisms in the context of GPCR and arrestin activation. 

A research summary of this NIH-funded position can be found here. The position will be available for two years (start date ASAP) with the possibility of extension. The successful candidate will possess a strong background in insect culture-based protein expression, membrane protein characterization, and structural biology. Applicants with NMR experience are highly desired, with at least an interest in state-of-the-art spectroscopy is required. Candidates should be highly motivated, open to new approaches and techniques, and be able to tackle demanding challenges. Our lab is committed to actively diversifying, supporting, and championing underrepresented groups in STEM. The facilities and space available to the Ziarek lab at Indiana University comprehensively include all the necessary equipment and resources. Indiana University proudly operates numerous core facilities each staffing at least one Ph.D. level scientist, for example: the Physical Biochemistry Instrumentation facility, Cryo-electron Microscopy facility, Biological NMR facility, Macromolecular Crystallography facility, Biological Mass Spectrometry facility, and the Chemical Genomics Core Facility.

 

Beautiful Indiana University resides in Bloomington, Indiana – a small city nestled in unglaciated hills within driving distance of many large metropolitan areas. It offers a vibrant cultural life, superb music, and a diverse international campus community. Bloomington is bordered by Yellowwood State Forest, Brown Country State Park, and Hoosier National Forest – providing nearly unlimited recreational opportunities and is consistently ranked as one of the most livable towns in the country. 

Best consideration date for applicants is September 7th, 2021, with a start date of early September.

 

Salary range starts at $47,000 annually and is commensurate with experience. The university offers excellent health insurance and benefits. Detailed benefit information can be found at http://hr.iu.edu/benefits/index.html#loaded .

 

Interested candidates with a PhD in biochemistry, chemistry or a related field with relevant experience should submit their application at https://indiana.peopleadmin.com/postings/11224. A completed application includes a curriculum vitae, and a brief summary of past research experience. The applicant should also arrange for the submission of two recommendation letters, if selected for employment. One of which must be from their PhD advisor. Inquiries regarding this position can directed to Dr. Joshua Ziarek at jjziarek@indiana.edu.

Professor Josh Ziarek, (jjziarek@indiana.edu)