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Job Summary

We are looking for applicants for a research assistant position in the Edward A. Doisy Department of Biochemistry and Molecular Biology, beginning in the spring of 2022. Successful candidates are expected to have a bachelors or masters degree in molecular & cell biology, biochemistry, or biophysics, with research experience in mammalian/insect cell culture protein expression. The laboratory of Dr. Reza Dastvan focuses on the molecular understanding of the cellular release mechanism of the brain-type creatine kinase and sphingosine kinase isoforms 1 and 2 as key therapeutic targets in a wide variety of neoplastic, cardiovascular, and neurodegenerative diseases. In addition, the lab investigates the structural dynamics of membrane transporters associated with the survival of metastatic cells. This position requires experience in protein expression and purification and standard molecular biology procedures, the ability to work in a team and knowledge of basic laboratory procedures and record keeping. The research assistant will support ongoing experiments in molecular biology, cell culture and protein expression/purification. Motivated individuals will have their own projects and perform structural biology related research. Additional responsibilities will include maintenance of common lab supplies including buffers and competent cells, organizing chemical stocks, etc.

Duties and Responsibilities

• Manage and maintain inventory of lab reagents and equipment
• Train new lab personnel and collaborators on equipment usage
• Generate constructs of protein of interest and carry out site directed mutagenesis
• Express proteins of interest in bacterial, insect or mammalian cells
• Purify proteins and perform quality control by standard biochemical methods
• Opportunity to perform independent research

Vaccine Protocol

Saint Louis University requires COVID-19 vaccinations and a