The Department of Molecular Pathobiology, at NYU College of Dentistry, is recruiting for a Postdoctoral Associate candidate for our newly initiated research program centered on compartmentalized G protein signaling by internalized G proteincoupled receptors (GPCRs) in the Thomsen lab. The main objective of the research program is to understand the mechanistic basis behind compartmentalized GPCR signaling at a near-atomic level, and to study its direct implications on a variety of physiological and pathophysiological conditions including cancer metastasis, nociception, and salt/water homeostasis.
The primary project of the successful candidate will be to investigate the mechanism and contribution of chemokine receptor signaling to cell migration and metastasis of melanoma cells. The project will involve work with primary metastatic tissue isolated from patients as well as melanoma cell lines where an in-depth mechanism of cell migration is sought through usage of interdisciplinary approaches including cell biology, protein chemistry, and structural biology. The insights learned from this project will be applied in the design of innovative biopharmaceutical drug candidates to combat metastatic melanoma. In addition, it is also expected that the applicant will participate in related secondary projects and collaborative projects within and/or outside our laboratory.
PhD and/or MD in Biomedical Research required. Candidates should also have experience in either cell biology, protein purification, and/or cryo-electron microscopy (cryo-EM). Prior knowledge of GPCR signal transduction is preferred but not essential. We are looking for motivated and creative individuals with a commitment to academic research who can work independently as well as in team-based projects. Good oral and written communication skills are musts.
Cellular and Molecular Biology: Cell culture, molecular cloning, cell migration assays, cellbased signaling assays, confocal and live cell fluorescence microscopy.
Protein Chemistry: Expression and purification of proteins in bacteria, sf9 insect cells, and mammalian cell suspensions.
Electron Microscopy: Grid preparation, cryo-EM, cryo-electron tomography, negative stain EM, data processing
Candidates should apply with a CV, three references and short letter of intent. Relevant documents should be addressed to Dr. Alex Thomsen, PhD, Assistant Professor, Department of Molecular Pathobiology, New York University College of Dentistry, 345 East 24th Street, Room 902A, New York, NY 10010
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